About physostigmine salicylate
Reversible acetylcholinesterase inhibitor
Used for
- Reverses severe antimuscarinic poisoning, such as atropine or some antihistamine toxicity.
- Treats selected cases of antimuscarinic delirium under close medical supervision.
Usual adult dose
For severe antimuscarinic poisoning: 0.5–2 mg intravenously slowly, repeated cautiously if needed, with continuous monitoring.
Usual dose in children
For severe antimuscarinic poisoning: 0.02 mg/kg intravenously slowly (maximum 0.5 mg per dose), repeated cautiously if needed.
Common side effects
- Slow or irregular heartbeat
- Seizures
- Excessive saliva, sweating, or vomiting
- Bronchospasm
Important warnings
- Administer only with continuous cardiac monitoring and resuscitation support.
- Can cause seizures or dangerous heart rhythm problems, especially if given rapidly.
- Avoid or use extreme caution with asthma, heart conduction disorders, or suspected tricyclic antidepressant poisoning.
- Use only when poisoning and clinical features justify treatment.
Pregnancy
Use only when clearly necessary; pregnancy safety information is limited.
Breastfeeding
Information is limited; use requires clinical assessment.
Interactions
- Other medicines that slow heart rate may increase cardiac effects.
- Cholinergic medicines can increase excessive cholinergic effects.
- Antimuscarinic medicines may oppose its effects.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.