About perampane l
Antiseizure medication (AMPA receptor antagonist)
Used for
- Add-on treatment for focal-onset seizures in adults and children aged 4 years and older.
- Add-on treatment for primary generalized tonic-clonic seizures in adults and children aged 12 years and older.
Usual adult dose
Usually starts at 2 mg once daily at bedtime; increased gradually, typically by 2 mg weekly, according to response and tolerability.
Usual dose in children
For focal seizures from age 4, and generalized tonic-clonic seizures from age 12: weight-based, once-daily bedtime dosing, increased gradually under specialist supervision.
Common side effects
- Dizziness, sleepiness, fatigue, and unsteadiness
- Falls and coordination problems
- Irritability, aggression, or other mood and behavior changes
- Nausea or weight gain
Important warnings
- Can cause serious aggression, hostility, or suicidal thoughts; monitor for behavior changes.
- May cause severe dizziness, sleepiness, falls, or impaired coordination.
- Do not stop suddenly; seizures may worsen.
- Dose adjustment may be needed with liver or kidney problems or interacting medicines.
Pregnancy
May harm an unborn baby; pregnancy registry data are limited. Seizures and treatment risks need specialist review.
Breastfeeding
It is unknown whether perampanel passes into breast milk; effects on a nursing infant are uncertain.
Interactions
- Carbamazepine, oxcarbazepine, and phenytoin can lower perampanel levels.
- Perampanel can reduce hormonal contraceptive effectiveness; additional contraception may be needed.
- Alcohol and other sedating medicines can worsen dizziness and sleepiness.
- May increase effects of some medicines, including midazolam.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.