About pemetrexed disodium
Antimetabolite chemotherapy (antifolate)
Used for
- Mesothelioma, usually with cisplatin
- Non-small-cell lung cancer, alone or with other medicines
Usual adult dose
Usually 500 mg/m² by intravenous infusion every 21 days; dose and schedule depend on cancer and combination treatment.
Common side effects
- Low blood cell counts and infection risk
- Nausea, vomiting, loss of appetite
- Fatigue and mouth sores
- Rash and kidney problems
Important warnings
- Folic acid and vitamin B12 are required to reduce toxicity.
- Dexamethasone is commonly used to reduce skin reactions.
- Blood counts and kidney function require monitoring.
- Avoid during pregnancy; can harm an unborn baby.
Pregnancy
Can cause fetal harm. Pregnancy should be avoided during treatment; reliable contraception is recommended.
Breastfeeding
Breastfeeding is not recommended during treatment and for at least one week after the last dose.
Interactions
- Ibuprofen and other NSAIDs may increase toxicity, especially with reduced kidney function.
- Other medicines that affect kidney function may increase pemetrexed exposure.
- Concurrent myelosuppressive medicines can increase low blood counts.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.