About pemetrexe d disodium
Antimetabolite chemotherapy (antifolate)
Used for
- Mesothelioma, usually with cisplatin
- Non-small cell lung cancer
Usual adult dose
Usually 500 mg/m² by intravenous infusion every 21 days; regimen depends on cancer and other medicines.
Common side effects
- Low blood cell counts
- Nausea and vomiting
- Fatigue
- Mouth sores or rash
Important warnings
- Can cause serious infection or bleeding from low blood counts.
- Kidney function must be checked; severe kidney impairment may prevent treatment.
- Folic acid and vitamin B12 are used to reduce toxicity.
- Avoid ibuprofen and similar medicines around treatment unless the oncology team approves.
Pregnancy
Can harm an unborn baby. Avoid during pregnancy; effective contraception is recommended during treatment and for six months afterward.
Breastfeeding
Breastfeeding is not recommended during treatment and for one week after the final dose.
Interactions
- Ibuprofen and other NSAIDs may increase toxicity, especially with reduced kidney function.
- Other medicines that affect kidney function or blood counts may increase adverse effects.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.