About pegzilarginase
Recombinant human arginase enzyme
Used for
- Treats hyperargininemia in adults and children with arginase 1 deficiency, alongside dietary management.
Usual adult dose
Intravenous infusion once weekly; dose is adjusted using body weight and blood arginine levels.
Usual dose in children
Intravenous infusion once weekly; dose is adjusted using body weight and blood arginine levels.
Common side effects
- Allergic or infusion-related reactions
- Vomiting
- Fever
- Headache
Important warnings
- May cause serious allergic reactions, including anaphylaxis.
- Blood arginine levels require monitoring to guide dosing.
- Not a substitute for prescribed dietary management.
- Use only under specialist medical supervision.
Pregnancy
There is limited information about use during pregnancy; the risks and benefits should be assessed by a specialist.
Breastfeeding
It is not known whether pegzilarginase passes into breast milk; specialist assessment is needed.
Interactions
- No major drug interactions are established; tell the treatment team about all medicines and supplements.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.