About pazopanib hcl
Tyrosine kinase inhibitor anticancer medicine
Used for
- Advanced kidney cancer
- Advanced soft-tissue sarcoma after prior chemotherapy
Usual adult dose
800 mg by mouth once daily on an empty stomach; dose may be adjusted for side effects or interactions.
Common side effects
- Diarrhea, nausea, vomiting, or loss of appetite
- High blood pressure
- Hair color changes or hair loss
- Abnormal liver tests
Important warnings
- Can cause severe or fatal liver injury; liver tests require monitoring.
- May cause high blood pressure, bleeding, blood clots, or heart problems.
- Can impair wound healing; treatment may need to stop before surgery.
- Avoid grapefruit; take on an empty stomach and avoid crushing tablets.
Pregnancy
May harm an unborn baby. Effective contraception is recommended during treatment and for at least two weeks afterward.
Breastfeeding
Breastfeeding is not recommended during treatment and for at least two weeks after the last dose.
Interactions
- Acid-reducing medicines can lower pazopanib levels.
- Strong CYP3A4 inhibitors or inducers can alter levels.
- May increase bleeding risk with anticoagulants or antiplatelet medicines.
- Avoid other medicines that prolong the QT interval when possible.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.