About pazopanib hcl
Tyrosine kinase inhibitor
Used for
- Advanced kidney cancer
- Advanced soft-tissue sarcoma
Usual adult dose
Usually 800 mg once daily on an empty stomach; dose may be adjusted for side effects.
Common side effects
- Diarrhea, nausea, vomiting, or loss of appetite
- High blood pressure
- Hair color changes
- Fatigue or abnormal liver tests
Important warnings
- Can cause serious liver injury; liver tests are monitored.
- May cause high blood pressure, heart problems, bleeding, or blood clots.
- Can impair wound healing; treatment is paused around major surgery.
- Avoid grapefruit; take on an empty stomach and swallow tablets whole.
Pregnancy
May harm an unborn baby. Avoid pregnancy during treatment and for at least two weeks after the last dose.
Breastfeeding
Do not breastfeed during treatment and for at least two weeks after the last dose.
Interactions
- Strong CYP3A4 inhibitors or inducers can alter drug levels.
- Avoid medicines that prolong the QT interval when possible.
- Acid-reducing medicines may lower absorption.
- Warfarin and other anticoagulants may increase bleeding risk.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.