About pasireotide aspartate
Somatostatin analogue
Used for
- Treats Cushing’s disease when surgery has not worked or is unsuitable.
- Treats acromegaly when surgery or other medicines have not worked adequately.
Usual adult dose
Cushing’s disease: 0.6–0.9 mg under the skin twice daily. Acromegaly: 40 mg by deep muscle injection every 28 days; dose may be adjusted.
Common side effects
- High blood sugar or diabetes
- Diarrhea, nausea, or abdominal pain
- Gallstones
- Slow heart rate or injection-site reactions
Important warnings
- Blood sugar can rise substantially; monitoring is required.
- Can cause gallstones and affect liver function or heart rhythm.
- Use caution with slow heart rate or medicines that prolong the QT interval.
- Different formulations and routes are not interchangeable.
Pregnancy
Human pregnancy data are limited; use only when clearly needed, as it may affect blood sugar and pregnancy hormones.
Breastfeeding
Breastfeeding is generally not recommended during treatment and for two weeks after the last dose.
Interactions
- Medicines that prolong QT interval may increase abnormal heart-rhythm risk.
- May affect levels of cyclosporine and other medicines cleared by CYP3A4.
- Diabetes medicines may need adjustment as blood sugar changes.
- Beta-blockers or other heart-rate-lowering medicines may increase slow-heart-rate risk.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.