About palopegteriparatide
Long-acting parathyroid hormone analogue
Used for
- Treats chronic hypoparathyroidism in adults to maintain calcium levels and reduce reliance on calcium and active vitamin D.
Usual adult dose
Usually starts at 18 micrograms under the skin once daily, adjusted gradually using blood calcium levels.
Common side effects
- Injection-site reactions
- Headache
- Nausea
- Low or high blood calcium
Important warnings
- Requires blood calcium monitoring during dose changes and treatment interruptions.
- Too much can cause high blood calcium; too little can cause dangerously low blood calcium.
- Not established for children; use is limited to adults.
- Avoid use in people at increased risk of osteosarcoma, such as those with Paget disease.
Pregnancy
Limited human data; potential benefits and risks should be assessed by a clinician.
Breastfeeding
It is unknown whether it passes into breast milk; effects on a nursing infant are uncertain.
Interactions
- Calcium supplements and active vitamin D can affect blood calcium and may need dose adjustment.
- Digoxin: changes in blood calcium may increase the risk of abnormal heart rhythms.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.