About palonosetron hydrochloride
Serotonin 5-HT3 receptor antagonist
Used for
- Prevention of nausea and vomiting from chemotherapy
- Prevention of nausea and vomiting after surgery
Usual adult dose
Chemotherapy: 0.25 mg intravenously once, about 30 minutes before treatment. Postoperative nausea: 0.075 mg intravenously once before anesthesia.
Usual dose in children
Chemotherapy: for ages 1 month to under 17 years, 20 micrograms/kg intravenously once, maximum 1.5 mg, before treatment.
Common side effects
- Headache
- Constipation
- Dizziness
- Injection-site discomfort
Important warnings
- Allergic reactions can occur.
- May prolong the heart’s QT interval, especially with risk factors.
- Serotonin syndrome is possible with other serotonergic medicines.
- May mask progressive bowel blockage symptoms.
Pregnancy
Human pregnancy information is limited; use when clinically needed after considering potential benefits and risks.
Breastfeeding
It is unknown whether palonosetron passes into human milk; breastfeeding data are limited.
Interactions
- Serotonergic medicines, including some antidepressants, may increase serotonin syndrome risk.
- Medicines that prolong QT interval may increase abnormal heart rhythm risk.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.