About palonosetron hcl
5-HT3 serotonin receptor antagonist
Used for
- Prevention of nausea and vomiting after surgery.
- Prevention of nausea and vomiting caused by chemotherapy.
Usual adult dose
For chemotherapy: 0.25 mg intravenously once before treatment. For surgery: 0.075 mg intravenously once before anesthesia.
Usual dose in children
For chemotherapy in children aged 1 month and older: 20 micrograms/kg intravenously, maximum 1.5 mg, before treatment. Not established for surgery.
Common side effects
- Headache
- Constipation
- Dizziness
- Injection-site pain
Important warnings
- Can cause serious allergic reactions.
- May affect heart rhythm, especially with other risk factors or medicines.
- Serotonin syndrome is possible with other medicines that increase serotonin.
- Use caution with severe constipation or bowel obstruction.
Pregnancy
Human pregnancy information is limited; use only when clearly needed.
Breastfeeding
It is not known whether palonosetron passes into breast milk; consider the medicine’s necessity and infant monitoring.
Interactions
- Other medicines that prolong the QT interval may increase abnormal heart-rhythm risk.
- Serotonergic medicines may increase serotonin syndrome risk.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.