About paclitaxel protein bound particles
Antineoplastic taxane chemotherapy
Used for
- Breast cancer that has spread or returned
- Non-small cell lung cancer, with carboplatin
- Pancreatic cancer that has spread, with gemcitabine
Usual adult dose
Doses depend on cancer type and body surface area, given by intravenous infusion on scheduled treatment days.
Common side effects
- Low blood cell counts and increased infection risk
- Numbness, tingling, or pain in hands and feet
- Hair loss
- Nausea, diarrhea, or fatigue
Important warnings
- Can cause severe bone marrow suppression and infection.
- May cause nerve damage; symptoms can worsen with continued treatment.
- Liver impairment may require dose changes; severe impairment may preclude use.
- Use only under specialist supervision; pregnancy must be avoided during treatment.
Pregnancy
May harm an unborn baby. Avoid pregnancy during treatment and for at least six months afterward; men should avoid fathering a child for at least three months afterward.
Breastfeeding
Breastfeeding is not recommended during treatment and for two weeks after the last dose.
Interactions
- Other medicines that suppress bone marrow can increase infection and bleeding risks.
- Strong CYP2C8 or CYP3A4 inhibitors may increase paclitaxel exposure.
- Strong CYP2C8 or CYP3A4 inducers may reduce paclitaxel exposure.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.