About osilodrostat phosphate
Cortisol synthesis inhibitor
Used for
- Treats Cushing’s disease in adults when surgery is not possible or has not cured the condition.
Usual adult dose
Usually starts at 2 mg twice daily; adjusted gradually according to cortisol levels and tolerability. Maximum 30 mg twice daily.
Common side effects
- Low cortisol levels
- Nausea, headache, or fatigue
- Swelling or high blood pressure
- Abnormal heart rhythm or prolonged QT interval
Important warnings
- Can cause dangerously low cortisol; monitoring and dose adjustment are essential.
- May prolong the QT interval and cause serious heart rhythm problems.
- May raise androgen levels, causing acne or excess hair growth.
- Do not stop suddenly without medical supervision.
Pregnancy
May cause fetal harm by reducing cortisol; human pregnancy data are limited.
Breastfeeding
It is unknown whether osilodrostat passes into breast milk; breastfeeding is not recommended during treatment.
Interactions
- QT-prolonging medicines may increase abnormal heart rhythm risk.
- Strong CYP3A4 inducers may lower osilodrostat levels.
- Osilodrostat can affect medicines processed by CYP enzymes, including some statins and hormones.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.