About osilodros tat phosphate
Cortisol synthesis inhibitor
Used for
- Treats Cushing’s syndrome in adults when surgery is unsuitable or has not cured the condition.
Usual adult dose
Usually starts at 2 mg twice daily. The dose is adjusted according to cortisol levels and tolerability; maximum 30 mg twice daily.
Common side effects
- Low cortisol
- Nausea or vomiting
- Headache
- High blood pressure or low potassium
Important warnings
- Can cause dangerously low cortisol; monitoring and dose changes may be needed.
- May prolong the heart’s electrical recovery (QT interval), increasing risk of abnormal rhythms.
- Can cause low potassium or high blood pressure; blood tests and blood-pressure checks are important.
- Can affect liver tests and may cause adrenal insufficiency.
Pregnancy
May harm an unborn baby; pregnancy status should be checked before treatment. Human pregnancy data are limited.
Breastfeeding
It is not known whether osilodrostat passes into breast milk; breastfeeding is generally not recommended during treatment.
Interactions
- Other medicines that prolong the QT interval can increase heart-rhythm risks.
- Strong CYP3A4 inhibitors or inducers may change osilodrostat levels.
- Osilodrostat can affect medicines processed by CYP enzymes, including some hormonal contraceptives.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.