About orlistat + milled
Gastrointestinal lipase inhibitor
Used for
- Weight loss alongside a reduced-calorie, lower-fat diet in adults with overweight or obesity
Usual adult dose
60 mg by mouth with each fat-containing meal, up to three times daily; omit if meal is skipped or fat-free.
Common side effects
- Oily spotting or leakage
- Gas with oily discharge
- Urgent or more frequent bowel movements
- Abdominal discomfort
Important warnings
- A very low-fat diet can reduce digestive side effects.
- May reduce absorption of fat-soluble vitamins; a multivitamin is often taken separately.
- Avoid with chronic malabsorption or cholestasis.
- Weight loss may affect warfarin control; monitoring may be needed.
Pregnancy
Not recommended for weight loss during pregnancy.
Breastfeeding
Use is generally not recommended while breastfeeding because safety information is limited.
Interactions
- Cyclosporine: reduced absorption; separate doses and monitor levels.
- Warfarin: weight loss or reduced vitamin K absorption may alter anticoagulation.
- Levothyroxine: separate by at least four hours; thyroid monitoring may be needed.
- Some seizure medicines, HIV medicines, or amiodarone may have reduced absorption or effectiveness.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.