About orforglipron
Oral GLP-1 receptor agonist
Used for
- Chronic weight management in adults with obesity or overweight and weight-related conditions
Usual adult dose
Taken once daily, with gradual dose increases about every 30 days. Usual maintenance doses are 12 or 36 mg daily, depending on response and tolerability.
Common side effects
- Nausea, diarrhea, constipation, or vomiting
- Abdominal discomfort or indigestion
- Reduced appetite
- Gallbladder problems
Important warnings
- Not for people with a personal or family history of medullary thyroid cancer or MEN2.
- Can cause pancreatitis, gallbladder problems, dehydration, or severe stomach symptoms.
- May increase heart rate; monitor for allergic reactions.
- Can affect absorption of oral medicines; discuss medicines needing reliable absorption.
Pregnancy
Weight loss offers no benefit during pregnancy and may harm the fetus; discontinue if pregnancy occurs.
Breastfeeding
Human milk data are limited; discuss treatment with a healthcare professional while breastfeeding.
Interactions
- May affect absorption of oral medicines, including hormonal contraceptives.
- May increase low blood sugar risk with insulin or sulfonylureas.
- May affect absorption of medicines with a narrow therapeutic range.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.