About ondasetro n hydrochlo
5-HT3 receptor antagonist antiemetic
Used for
- Prevention and treatment of nausea and vomiting caused by chemotherapy or radiotherapy
- Prevention and treatment of postoperative nausea and vomiting
Usual adult dose
Usually 4–8 mg by injection, depending on the cause and treatment protocol.
Usual dose in children
For chemotherapy-related nausea, usually 0.15 mg/kg intravenously per dose, up to 8 mg; protocol-dependent.
Common side effects
- Headache
- Constipation or diarrhoea
- Flushing
- Injection-site reactions
Important warnings
- Can prolong the QT interval and rarely cause serious abnormal heart rhythms.
- Use caution with heart rhythm problems, low potassium or magnesium, or other QT-prolonging medicines.
- Can mask signs of bowel blockage; constipation may occur.
- Rarely causes severe allergic reactions or serotonin syndrome.
Pregnancy
Use only when clinically needed; safety information is limited, especially early in pregnancy.
Breastfeeding
Breastfeeding safety is uncertain; discuss use with a healthcare professional.
Interactions
- Apomorphine: combination is contraindicated because of severe low blood pressure and loss of consciousness.
- Medicines that prolong the QT interval can increase heart-rhythm risk.
- Serotonergic medicines may increase the risk of serotonin syndrome.
- Strong enzyme-inducing medicines, such as rifampicin, may reduce ondansetron effects.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.