About ondansetron base
5-HT3 receptor antagonist antiemetic
Used for
- Prevention and treatment of nausea and vomiting from chemotherapy
- Prevention and treatment of nausea and vomiting after surgery
- Treatment of nausea and vomiting from radiotherapy
Usual adult dose
Usually 8 mg by mouth every 8–12 hours, depending on the cause and treatment plan.
Usual dose in children
For chemotherapy-related nausea, usually 0.15 mg/kg per dose every 8 hours, up to 8 mg per dose; dosing depends on age and treatment.
Common side effects
- Headache
- Constipation
- Diarrhea
- Dizziness
Important warnings
- May prolong the heart’s QT interval and rarely cause serious rhythm problems.
- Seek urgent care for fainting, severe palpitations, or signs of an allergic reaction.
- Can mask symptoms of bowel blockage.
- Use caution with severe liver disease; the maximum dose may need limiting.
Pregnancy
May be used when clinically needed; pregnancy safety evidence is mixed, so benefits and risks should be considered.
Breastfeeding
Limited information is available; discuss use with a healthcare professional, especially for newborn or premature infants.
Interactions
- Apomorphine: combination can cause dangerously low blood pressure and loss of consciousness.
- Other QT-prolonging medicines may increase heart-rhythm risk.
- Serotonergic medicines may rarely increase serotonin-syndrome risk.
- Strong enzyme-inducing medicines, such as rifampicin, may reduce ondansetron levels.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.