About olanzapine usp
Second-generation antipsychotic
Used for
- Schizophrenia
- Bipolar I disorder, including manic or mixed episodes
- Prevention of recurrent bipolar episodes
Usual adult dose
Schizophrenia: usually 5–10 mg once daily initially; typical range 5–20 mg daily. Bipolar mania: usually 10–15 mg once daily.
Usual dose in children
For ages 13–17 with schizophrenia or bipolar mania: usually 2.5–5 mg once daily initially; typical range 2.5–20 mg daily.
Common side effects
- Sleepiness, dizziness, or weakness
- Increased appetite and weight gain
- Dry mouth or constipation
- Raised blood sugar or cholesterol
Important warnings
- Can cause major weight gain and metabolic changes, including diabetes.
- May cause sleepiness, dizziness, or impaired coordination; falls can occur.
- Older adults with dementia-related psychosis have increased risk of death; not approved for this use.
- Do not stop suddenly without medical guidance; symptoms may return.
Pregnancy
Use during pregnancy only when benefits outweigh risks; newborns may have movement problems or withdrawal symptoms after late-pregnancy exposure.
Breastfeeding
Olanzapine enters breast milk; discuss potential infant sleepiness or feeding problems with a clinician.
Interactions
- Alcohol and sedatives can worsen sleepiness and impaired coordination.
- Fluvoxamine may increase olanzapine levels.
- Carbamazepine and smoking may lower olanzapine levels.
- Other medicines affecting blood pressure or blood sugar may increase related risks.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.