About ofatumuma b
Anti-CD20 monoclonal antibody
Used for
- Treats relapsing forms of multiple sclerosis in adults.
Usual adult dose
Injected under the skin weekly for three doses, then monthly starting one week later.
Common side effects
- Injection-related reactions, such as fever, headache, and chills
- Upper respiratory infections
- Urinary tract infections
- Low levels of certain antibodies
Important warnings
- Can cause serious infections; screening for hepatitis B is required before treatment.
- Vaccines may work less well; avoid live vaccines during treatment and until B-cell recovery.
- Treatment can reactivate hepatitis B or, rarely, cause progressive multifocal leukoencephalopathy.
- Monitor immune cell and antibody levels as clinically appropriate.
Pregnancy
Human pregnancy data are limited. It may harm a fetus; discuss pregnancy planning with a clinician.
Breastfeeding
It is unknown whether ofatumumab passes into human milk. Consider potential infant exposure and treatment benefits with a clinician.
Interactions
- Live vaccines may cause infection and should be avoided during treatment.
- Other immune-suppressing medicines may increase infection risk or immune effects.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.