About nirogacestat
Gamma-secretase inhibitor
Used for
- Treatment of progressing desmoid tumors in adults requiring systemic treatment.
Usual adult dose
150 mg by mouth twice daily; reduce or interrupt for side effects.
Common side effects
- Diarrhea
- Ovarian toxicity, including irregular periods or reduced fertility
- Rash
- Nausea and fatigue
Important warnings
- Can cause severe diarrhea and dehydration.
- May impair ovarian function and fertility; fetal harm is possible.
- May cause electrolyte abnormalities, liver enzyme increases, or non-melanoma skin cancers.
- Avoid strong or moderate CYP3A inhibitors and inducers, and proton pump inhibitors.
Pregnancy
May cause fetal harm. Pregnancy should be avoided during treatment and for one week after the last dose.
Breastfeeding
Do not breastfeed during treatment and for one week after the last dose.
Interactions
- Strong or moderate CYP3A inhibitors can raise drug levels.
- CYP3A inducers can lower drug levels.
- Proton pump inhibitors can reduce absorption.
- May reduce effectiveness of hormonal contraceptives.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.