About nirmatrelv ir
Antiviral combination
Used for
- Treats mild-to-moderate COVID-19 in people at increased risk of severe illness.
Usual adult dose
Nirmatrelvir 300 mg plus ritonavir 100 mg by mouth twice daily for 5 days; dose adjustment may be needed for kidney impairment.
Usual dose in children
For children aged 12 years or older weighing at least 40 kg: same dose as adults; kidney impairment may require adjustment.
Common side effects
- Altered taste
- Diarrhea
- High blood pressure
- Muscle aches
Important warnings
- Start within 5 days of symptom onset.
- Not recommended for severe kidney or liver impairment; kidney dose adjustment may be required.
- Ritonavir can cause serious interactions with many medicines.
- COVID-19 symptoms may return after treatment.
Pregnancy
Human pregnancy data are limited. COVID-19 illness itself can pose risks during pregnancy; treatment decisions require clinical assessment.
Breastfeeding
Limited information is available. Consider the benefits of breastfeeding and treatment, and the potential risks to the infant.
Interactions
- Some medicines can cause dangerous interactions; check all prescription, over-the-counter, and herbal products.
- Certain medicines may need temporary interruption or dose changes during treatment.
- Avoid St John’s wort; it can reduce treatment effectiveness.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.