About niraparib
PARP inhibitor and androgen receptor inhibitor
Used for
- Treats certain advanced prostate cancers with a BRCA mutation, with abiraterone and prednisone or prednisolone.
Usual adult dose
One tablet once daily with abiraterone and prednisone or prednisolone; dose may be adjusted by a specialist.
Common side effects
- Low blood counts, including anemia and low platelets
- High blood pressure
- Fatigue, nausea, or constipation
- Low potassium or swelling
Important warnings
- Can cause serious bone marrow problems, including rare blood cancers.
- Blood pressure and blood counts need regular monitoring.
- May cause liver problems; liver tests need monitoring.
- Contains abiraterone, which can harm an unborn baby; men should use contraception during treatment.
Pregnancy
Not for use in pregnancy; abiraterone may harm an unborn baby.
Breastfeeding
Not for use while breastfeeding.
Interactions
- Strong CYP3A4 inducers can reduce abiraterone levels.
- Some medicines that prolong the QT interval may increase heart rhythm risks.
- Food increases abiraterone absorption; take on an empty stomach.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.