About nintedanib
Tyrosine kinase inhibitor
Used for
- Idiopathic pulmonary fibrosis
- Progressive fibrosing interstitial lung diseases
- Interstitial lung disease associated with systemic sclerosis
Usual adult dose
Usually 150 mg by mouth twice daily with food; 100 mg twice daily may be used for side effects or liver problems.
Common side effects
- Diarrhea
- Nausea and vomiting
- Abdominal pain
- Liver enzyme increases
Important warnings
- Can cause serious liver injury; liver tests are needed before and during treatment.
- May increase bleeding risk and rarely cause gastrointestinal perforation.
- Can harm an unborn baby; effective contraception is needed during treatment.
- Seek medical attention for severe diarrhea, unusual bleeding, or severe abdominal pain.
Pregnancy
Can cause fetal harm. Avoid during pregnancy; effective contraception is recommended during treatment and for at least three months afterward.
Breastfeeding
Breastfeeding is not recommended during treatment because of potential serious harm to the infant.
Interactions
- Strong P-glycoprotein or CYP3A4 inhibitors can increase nintedanib exposure.
- P-glycoprotein or CYP3A4 inducers can reduce nintedanib exposure.
- Blood thinners may increase bleeding risk; monitoring may be needed.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.