About nilotinib
BCR-ABL tyrosine kinase inhibitor
Used for
- Treats certain types of Philadelphia chromosome-positive chronic myeloid leukemia (CML).
Usual adult dose
Usually 300 mg twice daily for newly diagnosed CML, or 400 mg twice daily for resistant or intolerant CML.
Common side effects
- Low blood counts
- Rash, itching, or headache
- Nausea, diarrhea, or constipation
- Raised blood sugar or liver enzymes
Important warnings
- Can prolong the heart rhythm and cause serious arrhythmias.
- May cause low blood counts, pancreatitis, or liver problems.
- Take on an empty stomach; avoid food for two hours before and one hour after.
- Requires blood tests and heart monitoring.
Pregnancy
May harm an unborn baby. Effective contraception is recommended during treatment and for at least 14 days afterward.
Breastfeeding
Breastfeeding is not recommended during treatment and for at least 14 days after the last dose.
Interactions
- Strong CYP3A4 inhibitors or inducers can change nilotinib levels.
- Avoid medicines that prolong the QT interval.
- Avoid grapefruit and grapefruit juice.
- Acid-reducing medicines may affect absorption.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.