About netupitant + palonosetron
NK1 antagonist and 5-HT3 antagonist
Used for
- Prevention of nausea and vomiting caused by cancer chemotherapy
Usual adult dose
One capsule by mouth about 1 hour before chemotherapy, usually with dexamethasone.
Common side effects
- Headache
- Constipation
- Tiredness
- Indigestion
Important warnings
- May cause allergic reactions, including severe reactions.
- Can affect heart rhythm; risk may be higher with other QT-prolonging medicines.
- May cause serotonin syndrome with certain antidepressants or other serotonergic medicines.
- Can reduce hormonal contraceptive effectiveness; use additional non-hormonal contraception as directed.
Pregnancy
Human pregnancy data are limited. Use during pregnancy only when clearly needed after medical review.
Breastfeeding
It is unknown whether these medicines pass into breast milk. Breastfeeding decisions require medical review.
Interactions
- Strong CYP3A4 inhibitors can increase netupitant exposure.
- Strong CYP3A4 inducers can reduce effectiveness.
- Netupitant can alter levels of CYP3A4-metabolized medicines, including some chemotherapy drugs.
- Serotonergic medicines may increase serotonin syndrome risk.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.