About neostigmine
Acetylcholinesterase inhibitor
Used for
- Reverses certain muscle-relaxing medicines after surgery.
- Treats myasthenia gravis in some settings.
- Helps prevent or treat postoperative bowel or bladder inactivity.
Usual adult dose
Varies by use and route; commonly 0.5–2.5 mg by injection for reversal of muscle relaxation, with monitoring.
Usual dose in children
Specialist-determined, weight-based dosing for selected uses; requires close monitoring.
Common side effects
- Slow heartbeat
- Increased saliva and sweating
- Nausea, vomiting, or diarrhea
- Muscle cramps or twitching
Important warnings
- Can cause dangerously slow heartbeat or breathing problems.
- May worsen asthma or cause increased airway secretions.
- Use cautiously with heart rhythm problems, ulcers, or urinary obstruction.
- Overdose can cause severe weakness, seizures, or respiratory failure.
Pregnancy
Use only when clinically needed; evidence is limited, and treatment requires specialist assessment.
Breastfeeding
Information is limited; discuss use with a clinician, particularly for newborn or premature infants.
Interactions
- Other cholinergic medicines can intensify effects and side effects.
- Anticholinergic medicines, such as atropine, can alter its effects.
- Some antibiotics and anesthetics may affect muscle strength or response.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.