About neostigmin e
Acetylcholinesterase inhibitor
Used for
- Reverses certain muscle-relaxing medicines after surgery
- Treats myasthenia gravis
- May help prevent or treat postoperative urinary retention
Usual adult dose
Dose depends on use and route; commonly 0.5–2.5 mg by injection to reverse muscle relaxation, with an anticholinergic medicine.
Usual dose in children
For reversal of muscle relaxation, specialist dosing is weight-based, commonly 0.05 mg/kg by injection, with an anticholinergic medicine.
Common side effects
- Slow heartbeat
- Nausea, vomiting, or diarrhoea
- Increased saliva and sweating
- Muscle cramps or weakness
Important warnings
- Injection requires medical supervision and heart monitoring.
- Excess can cause severe weakness, breathing problems, and dangerously slow heartbeat.
- Use cautiously with asthma, heart-rhythm problems, or bowel or urinary obstruction.
- An anticholinergic medicine is usually given alongside it for surgical reversal.
Pregnancy
Use only when clearly needed; evidence is limited, and the decision should be made by a clinician.
Breastfeeding
Information is limited; use under medical supervision, considering the mother's need and potential infant effects.
Interactions
- Other medicines that slow heart rate may increase risk of bradycardia.
- Muscle-relaxing medicines may oppose or alter its effects.
- Other cholinergic medicines can increase side effects.
- Anticholinergic medicines alter its effects and are commonly paired during surgical reversal.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.