About natalizuma b
Monoclonal antibody; integrin inhibitor
Used for
- Relapsing forms of multiple sclerosis
- Moderate to severe Crohn’s disease when other treatments fail or are unsuitable
Usual adult dose
300 mg by intravenous infusion every four weeks for multiple sclerosis or Crohn’s disease.
Common side effects
- Headache, fatigue, dizziness
- Nausea or joint pain
- Infusion reactions
- Infections
Important warnings
- Can cause progressive multifocal leukoencephalopathy, a rare, potentially fatal brain infection.
- Risk increases with JC virus antibodies, longer treatment, and prior immunosuppressant use.
- Treatment requires specialist monitoring and a risk-management program.
- Serious allergic reactions and liver injury can occur.
Pregnancy
Use only if clearly needed; discuss potential risks and benefits with a specialist. Effects on the unborn baby are uncertain.
Breastfeeding
Natalizumab passes into breast milk; effects on the infant are uncertain. Discuss risks and benefits with a healthcare professional.
Interactions
- Avoid combining with other immunosuppressants or biologic therapies because infection risks may rise.
- Prior immunosuppressant treatment increases the risk of progressive multifocal leukoencephalopathy.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.