About oxycodone hcl + naloxone hcl dihydrate
Opioid analgesic and opioid antagonist
Used for
- Severe, persistent pain requiring continuous opioid treatment
Usual adult dose
Usually one prolonged-release tablet every 12 hours; dose is individualized and adjusted by a prescriber.
Common side effects
- Constipation
- Nausea or vomiting
- Sleepiness or dizziness
- Headache
Important warnings
- Can cause dependence, overdose, and dangerously slow breathing.
- Avoid alcohol and use caution with sedatives or other opioids.
- Swallow tablets whole; crushing or chewing can release a dangerous dose.
- Not suitable for sudden or short-term pain.
Pregnancy
Use during pregnancy may cause newborn withdrawal or breathing problems; medical supervision is essential.
Breastfeeding
Oxycodone can pass into breast milk and cause infant sleepiness or breathing problems; generally not recommended.
Interactions
- Alcohol, benzodiazepines, and other sedatives increase breathing and sedation risks.
- Strong CYP3A4 inhibitors or inducers can change oxycodone levels.
- Other opioids or opioid antagonists may alter pain relief or withdrawal risk.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.