About metyrapone
Adrenal steroid synthesis inhibitor
Used for
- Tests adrenal gland function by measuring cortisol response.
- Treats Cushing syndrome by reducing cortisol production.
Usual adult dose
Cushing syndrome: typically 250 mg to 6 g daily in divided doses, adjusted to cortisol levels. Testing doses vary by protocol.
Usual dose in children
Cushing syndrome: specialist-directed, commonly 15–30 mg/kg daily in divided doses; maximum 6 g daily.
Common side effects
- Nausea, vomiting, abdominal discomfort, or diarrhea
- Dizziness, headache, or sleepiness
- Low cortisol, causing weakness or low blood pressure
- Increased blood pressure or low potassium
Important warnings
- Can cause dangerously low cortisol; monitoring and replacement treatment may be needed.
- May worsen high blood pressure, low potassium, or fluid retention.
- Use caution with liver or kidney problems.
- Testing protocols require clinical supervision and timed hormone measurements.
Pregnancy
Use only when clearly needed under specialist supervision; inadequate cortisol control can harm both pregnant person and fetus.
Breastfeeding
Information is limited; discuss use with a clinician, especially during prolonged treatment.
Interactions
- Steroids such as hydrocortisone may counteract its cortisol-lowering effect.
- Medicines affecting liver enzymes can alter metyrapone levels.
- It can change results of hormone tests and some laboratory assays.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.