About sitagliptin hydrochloride + metformin hydrochloride
DPP-4 inhibitor plus biguanide
Used for
- Improves blood sugar control in adults with type 2 diabetes, alongside diet and exercise.
Usual adult dose
Usually one tablet twice daily with meals; dose depends on kidney function and prior treatment.
Common side effects
- Diarrhea, nausea, vomiting, or stomach discomfort
- Headache or upper respiratory symptoms
- Low blood sugar, especially with insulin or sulfonylureas
Important warnings
- Not for type 1 diabetes or diabetic ketoacidosis.
- Metformin can rarely cause life-threatening lactic acidosis.
- Avoid with severe kidney impairment; kidney function should be checked.
- Seek urgent care for severe persistent abdominal pain, which may indicate pancreatitis.
Pregnancy
Use during pregnancy requires clinician review; insulin is generally preferred for diabetes management.
Breastfeeding
Discuss with a clinician; metformin enters breast milk, and breastfeeding data for sitagliptin are limited.
Interactions
- Insulin or sulfonylureas increase low blood sugar risk.
- Alcohol increases lactic acidosis risk with metformin.
- Some drugs, including carbonic anhydrase inhibitors, can increase lactic acidosis risk.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.