About mesna
Uroprotective agent
Used for
- Prevents ifosfamide-related bladder inflammation and bleeding.
- May be used with high-dose cyclophosphamide to reduce bladder toxicity.
Usual adult dose
For ifosfamide, typically a total mesna dose equal to 60% of the ifosfamide dose, divided around each ifosfamide dose; schedules vary.
Usual dose in children
For ifosfamide, typically a total mesna dose equal to 60% of the ifosfamide dose, divided around each dose; schedules vary.
Common side effects
- Nausea or vomiting
- Headache
- Flushing or rash
- Injection-site reactions
Important warnings
- Does not prevent other toxic effects of ifosfamide or cyclophosphamide.
- Rare severe allergic or skin reactions can occur.
- Dose timing and hydration are important for bladder protection.
- Blood in urine requires prompt medical assessment.
Pregnancy
Human pregnancy data are limited; use requires consideration of potential fetal risks and treatment benefits.
Breastfeeding
It is not known whether mesna passes into human milk; breastfeeding decisions depend on concurrent chemotherapy.
Interactions
- No major direct interactions are established; mesna is given alongside chemotherapy under specialist protocols.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.