About melperone hydrochloride
First-generation antipsychotic
Used for
- Schizophrenia and other psychotic disorders
- Agitation or restlessness, particularly in older adults
Usual adult dose
Usually 25–100 mg two or three times daily; adjusted to response and local prescribing guidance.
Common side effects
- Sleepiness or dizziness
- Low blood pressure, especially on standing
- Dry mouth or constipation
- Movement problems, including tremor or stiffness
Important warnings
- May cause severe sleepiness and increase falls risk.
- Can affect heart rhythm; caution with heart disease or medicines that prolong QT.
- Older adults with dementia-related psychosis have increased risk of death with antipsychotics.
- Avoid alcohol; do not stop long-term treatment abruptly without clinical guidance.
Pregnancy
Use only when clearly needed after weighing risks; newborns may have withdrawal or movement symptoms after late-pregnancy exposure.
Breastfeeding
May pass into breast milk; safety is uncertain, so use requires clinical assessment.
Interactions
- Alcohol, opioids, and sedatives can increase drowsiness.
- Other medicines that prolong QT can increase abnormal heart rhythm risk.
- Blood-pressure-lowering medicines can worsen dizziness or fainting.
- Levodopa and dopamine agonists may have reduced effects.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.