About meanv a camt
Cardiac myosin inhibitor
Used for
- Symptomatic obstructive hypertrophic cardiomyopathy in adults
Usual adult dose
Mavacamten usually starts at 5 mg once daily, adjusted between 2.5 and 15 mg daily according to echocardiograms and response.
Common side effects
- Dizziness
- Fainting
- Reduced heart pumping function
- Heart failure
Important warnings
- Can cause heart failure by reducing heart pumping strength.
- Echocardiograms are required before and regularly during treatment.
- Treatment should not start if ejection fraction is below 55%.
- Starting, stopping, or changing interacting medicines can cause serious harm.
Pregnancy
May harm an unborn baby. Effective contraception is required during treatment and for four months afterward; some hormonal contraceptives may be less effective.
Breastfeeding
Whether mavacamten enters human breast milk is unknown. Effects on breastfed babies and milk production are unknown.
Interactions
- CYP2C19 inhibitors, including omeprazole and fluconazole
- CYP3A4 inhibitors, including clarithromycin and certain antifungals
- Enzyme inducers, including rifampicin and St John's wort
- Other medicines reducing heart pumping strength, including certain combinations
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.