About maprotiline hydrochloride
Tetracyclic antidepressant
Used for
- Depression, including depression with anxiety or agitation
Usual adult dose
Usually 75–150 mg daily, taken once daily or in divided doses; doses are increased gradually.
Common side effects
- Dry mouth, constipation, blurred vision
- Drowsiness, dizziness, fatigue
- Fast heartbeat or low blood pressure
- Weight gain, sweating, tremor
Important warnings
- May increase suicidal thoughts, especially early in treatment or after dose changes.
- Can cause seizures; risk rises with higher doses and certain medical conditions.
- May trigger mania in people with bipolar disorder.
- Stopping suddenly may cause withdrawal symptoms; reduce gradually under medical supervision.
Pregnancy
Use only when clearly needed after weighing benefits and risks; seek clinical guidance before use.
Breastfeeding
Maprotiline may pass into breast milk; breastfeeding use requires clinical guidance.
Interactions
- Monoamine oxidase inhibitors: potentially dangerous reactions; avoid concurrent use.
- Other medicines that cause drowsiness may worsen sedation.
- Medicines that affect heart rhythm may increase cardiac risks.
- Some antidepressants and other medicines can raise maprotiline levels or seizure risk.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.