About macitentan
Endothelin receptor antagonist
Used for
- Treats pulmonary arterial hypertension to improve exercise ability and delay disease worsening.
Usual adult dose
10 mg by mouth once daily.
Common side effects
- Anemia
- Headache
- Nasopharyngitis
- Fluid retention
Important warnings
- Can harm an unborn baby; pregnancy must be excluded before treatment.
- May cause liver injury; liver tests may be needed.
- Can cause anemia and fluid retention.
- Use caution with severe liver disease.
Pregnancy
Do not use during pregnancy. It can cause serious birth defects; effective contraception and pregnancy testing are required during treatment and for one month afterward.
Breastfeeding
It is unknown whether macitentan passes into human breast milk; breastfeeding is generally avoided during treatment.
Interactions
- Strong CYP3A4 inhibitors, such as ketoconazole, may increase macitentan levels.
- Strong CYP3A4 inducers, such as rifampin, may reduce its effectiveness.
- Cyclosporine may increase macitentan exposure.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.