About macitentan + tadalafil
Endothelin receptor antagonist and PDE5 inhibitor
Used for
- Treats pulmonary arterial hypertension in adults to improve exercise ability and reduce clinical worsening.
Usual adult dose
One tablet by mouth once daily, with or without food.
Common side effects
- Headache
- Anemia
- Swelling of the legs or ankles
- Nasal congestion
Important warnings
- Can cause serious fetal harm; pregnancy must be avoided during treatment and for one month afterward.
- May lower blood pressure; seek urgent care for sudden vision or hearing loss, or an erection lasting over four hours.
- May cause fluid retention, anemia, or liver problems; monitoring is needed.
- Do not combine with nitrates or riociguat; avoid strong CYP3A inhibitors or inducers.
Pregnancy
Contraindicated; macitentan can cause major birth defects. Pregnancy testing and effective contraception are required during treatment and for one month after stopping.
Breastfeeding
Breastfeeding is not recommended during treatment; the effects on a nursing infant are unknown.
Interactions
- Nitrates or riociguat can cause dangerous low blood pressure.
- Strong CYP3A inhibitors, such as ketoconazole, can increase drug levels.
- Strong CYP3A inducers, such as rifampin, can reduce drug levels.
- Other blood-pressure-lowering medicines may increase dizziness or fainting.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.