About macitentan tadalafil
Endothelin receptor antagonist and PDE-5 inhibitor
Used for
- Treats pulmonary arterial hypertension in adults.
- Helps improve exercise ability and reduce the risk of disease worsening.
Usual adult dose
One tablet by mouth once daily, as prescribed by a specialist.
Common side effects
- Headache
- Anemia
- Swelling of the legs or ankles
- Nasal congestion
Important warnings
- Can cause serious harm to an unborn baby; pregnancy must be excluded and prevented during treatment.
- May lower blood pressure; dizziness or fainting can occur.
- Seek urgent care for sudden vision or hearing loss, or an erection lasting over four hours.
- Avoid nitrates and riociguat; they can cause a dangerous blood-pressure drop.
Pregnancy
Do not use during pregnancy. Effective contraception and regular pregnancy testing are required during treatment and for one month afterward.
Breastfeeding
It is not known whether the medicines pass into breast milk; breastfeeding is not recommended during treatment.
Interactions
- Nitrates, riociguat, and strong CYP3A4 inhibitors can cause serious interactions.
- Some antifungals, antibiotics, HIV medicines, and seizure medicines can alter drug levels.
- Other blood-pressure-lowering medicines may increase dizziness or fainting.
- Avoid grapefruit products unless the prescriber confirms they are suitable.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.