About macitentan
Endothelin receptor antagonist
Used for
- Pulmonary arterial hypertension to improve exercise ability and reduce clinical worsening.
Usual adult dose
10 mg by mouth once daily, with or without food.
Common side effects
- Anemia
- Headache
- Nasal congestion or sore throat
- Liver enzyme increases
Important warnings
- Can cause serious birth defects; pregnancy must be excluded before treatment and prevented during treatment.
- May reduce sperm production; discuss fertility concerns with a clinician.
- Monitor for liver problems and anemia.
- Seek urgent care for new or worsening fluid retention or breathing difficulty.
Pregnancy
Do not use during pregnancy. It can harm an unborn baby; effective contraception and pregnancy testing are required under applicable safety programs.
Breastfeeding
It is unknown whether macitentan passes into breast milk; breastfeeding is generally not recommended during treatment.
Interactions
- Strong CYP3A4 inducers, such as rifampin, may lower macitentan levels.
- Strong CYP3A4 inhibitors, such as ketoconazole, may raise macitentan levels.
- Cyclosporine may increase macitentan exposure.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.