About lurasidone hcl
Atypical antipsychotic
Used for
- Schizophrenia in adults and adolescents
- Depressive episodes associated with bipolar I disorder in adults and children
Usual adult dose
Schizophrenia: usually 40 mg once daily with food; bipolar depression: 20 mg once daily with food. Doses vary by condition.
Usual dose in children
Schizophrenia, ages 13–17: usually 40 mg once daily. Bipolar depression, ages 10–17: usually 20 mg once daily, with food.
Common side effects
- Sleepiness or restlessness
- Nausea
- Movement problems, including tremor or stiffness
- Weight or blood sugar changes
Important warnings
- Take with at least 350 calories of food.
- May cause serious movement disorders, including tardive dyskinesia.
- Can cause neuroleptic malignant syndrome, high blood sugar, or low blood pressure.
- Not approved for dementia-related psychosis in older adults; increased risk of death.
Pregnancy
May cause newborn movement or withdrawal symptoms when used late in pregnancy. Discuss risks with a healthcare professional.
Breastfeeding
May pass into breast milk; effects on nursing infants are uncertain. Discuss with a healthcare professional.
Interactions
- Avoid strong CYP3A4 inhibitors, such as clarithromycin and ketoconazole.
- Avoid strong CYP3A4 inducers, such as rifampin and carbamazepine.
- Grapefruit may increase lurasidone levels.
- Alcohol and sedating medicines may worsen sleepiness.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.