About lubiprostone
Chloride channel activator laxative
Used for
- Chronic idiopathic constipation in adults
- Irritable bowel syndrome with constipation in adult women
- Opioid-induced constipation in adults with chronic non-cancer pain
Usual adult dose
Chronic constipation: 24 mcg twice daily with food and water. IBS with constipation: 8 mcg twice daily. Opioid-induced constipation: 24 mcg twice daily.
Common side effects
- Nausea
- Diarrhea
- Headache
- Abdominal discomfort
Important warnings
- Avoid with known or suspected bowel obstruction.
- May cause severe diarrhea; stop and contact a clinician if it occurs.
- Dizziness or fainting can occur, often with diarrhea.
- Take with food and water to reduce nausea.
Pregnancy
Human pregnancy data are limited; animal studies showed fetal harm at high exposures. Use only when clearly needed.
Breastfeeding
It is unknown whether lubiprostone enters breast milk. Consider infant monitoring for diarrhea.
Interactions
- Methadone and other diphenylheptane opioids may reduce its effect.
- Strong or moderate CYP3A4 inhibitors may increase exposure.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.