About lorlatinib
ALK and ROS1 tyrosine kinase inhibitor
Used for
- Treats adults with ALK-positive advanced non-small cell lung cancer.
Usual adult dose
100 mg by mouth once daily, with or without food; continue until disease worsens or side effects become unacceptable.
Common side effects
- High cholesterol or triglycerides
- Swelling, numbness, or tingling
- Weight gain
- Changes in thinking, mood, speech, or sleep
Important warnings
- Can cause serious mood, thinking, speech, or sleep changes.
- Can cause severe lung inflammation and abnormal heart rhythm.
- Liver tests may need monitoring, especially with certain interacting medicines.
- May harm an unborn baby; effective contraception is important during treatment.
Pregnancy
May cause fetal harm. Pregnancy testing is recommended before treatment; contraception is needed during treatment and for seven months afterward.
Breastfeeding
Do not breastfeed during treatment or for seven days after the last dose.
Interactions
- Strong CYP3A inducers can cause serious liver injury and should be avoided.
- Strong CYP3A inhibitors can raise lorlatinib levels; dose adjustment may be needed.
- Lorlatinib can reduce hormonal contraceptive effectiveness.
- Can reduce levels of some medicines, including certain birth-control pills and transplant drugs.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.