About lopinavir
HIV protease inhibitor combination
Used for
- Treats HIV-1 infection with other antiretroviral medicines.
Usual adult dose
400 mg lopinavir/100 mg ritonavir twice daily, or 800 mg/200 mg once daily in selected adults.
Usual dose in children
For children aged 14 days or older, dosing is based on weight or body surface area; clinician-directed dosing is required.
Common side effects
- Diarrhea, nausea, or vomiting
- High triglycerides or cholesterol
- Liver enzyme changes
- Abnormal heart rhythm
Important warnings
- Not a cure for HIV; take with other prescribed HIV medicines.
- Can cause serious liver problems or pancreatitis.
- May affect heart rhythm or conduction.
- Contains alcohol and propylene glycol; special caution is needed in infants.
Pregnancy
Use during pregnancy only under specialist care; pregnancy can change dosing needs.
Breastfeeding
HIV can pass through breast milk; breastfeeding recommendations depend on local guidance and individual circumstances.
Interactions
- Many medicines interact, including rifampin and some seizure medicines.
- Can raise levels of certain statins, sedatives, and erectile dysfunction medicines.
- Do not combine with certain drugs that strongly affect CYP3A enzymes.
- Review all medicines and supplements with a clinician or pharmacist.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.