About loperamide hydrochloride
Antidiarrheal opioid-receptor agonist
Used for
- Short-term relief of acute diarrhea
- Symptom control of chronic diarrhea, including in some bowel disorders
Usual adult dose
Acute diarrhea: 4 mg initially, then 2 mg after each loose stool; maximum 16 mg daily. Follow product directions for nonprescription use.
Usual dose in children
Age 2 years and older: dosing depends on age and weight; use only under a clinician’s direction. Not for children under 2.
Common side effects
- Constipation
- Nausea
- Abdominal cramps
- Dizziness or drowsiness
Important warnings
- Do not use with bloody stools, high fever, or suspected bacterial diarrhea.
- Stop and seek medical care for abdominal swelling, severe constipation, or worsening symptoms.
- Excessive doses can cause fatal heart rhythm problems.
- Avoid exceeding label directions; use extra caution with liver disease.
Pregnancy
Use only when needed after discussing with a healthcare professional; evidence in pregnancy is limited.
Breastfeeding
Small amounts may enter breast milk; short-term use is generally considered compatible, but seek professional guidance.
Interactions
- Quinidine and ritonavir can increase loperamide levels.
- Gemfibrozil and itraconazole can raise levels and increase heart risks.
- Other medicines that affect heart rhythm may increase risk.
- Opioids and other medicines causing constipation may worsen constipation.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.