About lofexidine
Central alpha-2 adrenergic agonist
Used for
- Helps relieve opioid withdrawal symptoms during supervised detoxification.
Usual adult dose
Initially 0.18 mg four times daily; adjust as needed, maximum 0.72 mg daily. Usually used for up to 14 days.
Common side effects
- Low blood pressure, dizziness, or fainting
- Slow heart rate
- Sleepiness or sedation
- Dry mouth
Important warnings
- Can cause dangerous low blood pressure or slow heart rate.
- Stopping suddenly may raise blood pressure; taper under medical supervision.
- Avoid driving until effects on alertness are known.
- Use cautiously with heart rhythm problems or medicines that lower blood pressure.
Pregnancy
Human pregnancy data are limited; use only when a clinician determines benefits outweigh risks.
Breastfeeding
Whether lofexidine enters breast milk is unknown; breastfeeding safety has not been established.
Interactions
- Other medicines that slow heart rate or lower blood pressure
- Medicines that prolong the QT interval
- Sedatives, alcohol, or other medicines causing drowsiness
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.