About liposomal amphotericin b
Liposomal polyene antifungal
Used for
- Serious systemic fungal infections, including candidiasis and cryptococcosis
- Treatment of visceral leishmaniasis
- Empirical treatment of suspected fungal infection in certain patients with fever and low neutrophils
Usual adult dose
Usually 3–5 mg/kg intravenously once daily for fungal infections; regimen depends on infection. Visceral leishmaniasis dosing varies by region and protocol.
Usual dose in children
For serious fungal infections, usually 3–5 mg/kg intravenously once daily; specialist dosing depends on infection and age.
Common side effects
- Fever, chills, or infusion reactions
- Nausea, vomiting, or diarrhea
- Kidney problems and abnormal potassium or magnesium
- Anemia
Important warnings
- Given by intravenous infusion under medical supervision; not interchangeable with other amphotericin formulations.
- Kidney function, blood counts, potassium, and magnesium require monitoring.
- Serious allergic or infusion reactions can occur.
- Dose and duration depend on infection and patient factors.
Pregnancy
Use when clearly needed; evidence is limited, and the treating specialist weighs benefits and risks.
Breastfeeding
Information is limited; discuss use with a clinician, particularly when treating a serious infection.
Interactions
- Other kidney-harming medicines may increase kidney injury risk.
- Medicines that lower potassium, including some diuretics, can worsen low potassium.
- Corticosteroids and corticotropin may increase potassium loss.
- Digoxin and some muscle relaxants may be affected by low potassium.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.