About liposomal amphoteri cin b
Liposomal polyene antifungal
Used for
- Severe fungal infections, including invasive aspergillosis and candidiasis
- Cryptococcal meningitis in people with HIV
- Visceral leishmaniasis
Usual adult dose
Usually 3–5 mg/kg intravenously once daily for serious fungal infections; dosing depends on infection.
Usual dose in children
Usually 3–5 mg/kg intravenously once daily for serious fungal infections; specialist dosing depends on infection.
Common side effects
- Fever, chills, and infusion reactions
- Nausea, vomiting, or diarrhea
- Kidney injury and changes in potassium or magnesium
- Anemia
Important warnings
- Given by intravenous infusion under medical supervision; not interchangeable with other amphotericin formulations.
- Kidney function, blood counts, and electrolytes require monitoring.
- Infusion reactions can be severe; kidney injury and allergic reactions are possible.
- Use cautiously with existing kidney problems or medicines that can harm the kidneys.
Pregnancy
Use when needed for serious infection; available pregnancy information is limited, and treatment requires specialist assessment.
Breastfeeding
Information is limited; whether amphotericin B passes into breast milk is uncertain.
Interactions
- Other medicines that can harm the kidneys may increase kidney injury risk.
- Medicines that lower potassium, including some diuretics, may worsen low potassium.
- Flucytosine may have increased effects or toxicity.
- Corticosteroids and ACTH may worsen potassium loss.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.