About linagliptin + metformin
DPP-4 inhibitor and biguanide combination
Used for
- Improves blood sugar control in adults with type 2 diabetes, alongside diet and exercise.
Usual adult dose
Usually one tablet twice daily with meals; dosing depends on kidney function and prior treatment.
Common side effects
- Diarrhea, nausea, or stomach discomfort
- Low blood sugar, especially with insulin or sulfonylureas
- Cold-like symptoms
- Rarely, pancreatitis or severe allergic reactions
Important warnings
- Not for type 1 diabetes or diabetic ketoacidosis.
- Metformin can rarely cause serious lactic acidosis; risk rises with severe kidney problems or dehydration.
- Check kidney function before and during treatment; avoid with severe kidney impairment.
- Seek urgent care for persistent severe abdominal pain or signs of lactic acidosis, such as unusual weakness and rapid breathing.
Pregnancy
Use during pregnancy only if a clinician determines it is appropriate; insulin is often preferred for diabetes control.
Breastfeeding
Metformin enters breast milk; information on linagliptin is limited. Use requires clinician assessment.
Interactions
- Insulin and sulfonylureas increase low-blood-sugar risk.
- Rifampin may reduce linagliptin effectiveness.
- Carbonic anhydrase inhibitors, such as topiramate, may increase lactic-acidosis risk with metformin.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.