About letrozole ph eur
Aromatase inhibitor
Used for
- Treats hormone receptor-positive breast cancer after menopause.
- Used in fertility treatment to stimulate ovulation, sometimes off-label.
Usual adult dose
Breast cancer: 2.5 mg once daily. Fertility treatment: commonly 2.5–7.5 mg once daily for five days early in the menstrual cycle.
Common side effects
- Hot flushes and sweating
- Joint or muscle pain
- Tiredness and headache
- Nausea
Important warnings
- Can weaken bones and increase fracture risk.
- May cause dizziness or tiredness; caution with driving.
- Can harm an unborn baby; pregnancy must be excluded before treatment.
- Fertility use is off-label in some countries.
Pregnancy
Do not use during pregnancy; it may harm the fetus. Pregnancy should be excluded before treatment.
Breastfeeding
Avoid during breastfeeding; it is not known whether letrozole passes into human milk.
Interactions
- Tamoxifen and estrogen-containing medicines can reduce letrozole’s effect.
- Rifampicin, carbamazepine, phenytoin, or St John’s wort may alter letrozole levels.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.